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ea0029p806 | Endocrine tumours and neoplasia | ICEECE2012

Stem cell genes are deregulated in parathyroid tumours

Vaira V. , Verdelli C. , Forno I. , Elli F. , Guarnieri V. , Ferrero S. , Scillitani A. , Costa E. , Vicentini L. , Steffano G. , Cetani F. , Spada A. , Bosari S. , Corbetta S.

In our previous investigation on microRNAs expression pattern in parathyroid carcinomas (Ca), we detected the over-expression of microRNAs belonging to C19MC, the largest human cluster on chromosome 19q13.41. In the present study, the analysis of the expression of selected C19MC and the closely distal MIR371-3 clusters microRNAs (MIR512-3p, MIR517C, MIR520H and MIR372) was extended to 11 Ca, 24 adenomas (Ad) and 6 normal glands. The four microRNAs was expressed in 11% of parat...

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ea0026p56 | Endocrine tumours and neoplasia | ECE2011

The T-box transcription factor TBX1, the candidate gene of 22q11.2 microdeletion/DiGeorge syndrome, is involved in human parathyroid tumorigenesis

Verdelli C , Donnangelo A , Vaira V , Meregalli M , Belicchi M , Guarneri V , Scillitani A , Vicentini L , Cetani Filomena , Ferrero Stefano , Frigerio Marcello , Costa Elena , Ambrosi Bruno , Torrente Yvan , Bosari Silvano , Spada Anna , Corbetta Sabrina

The embryonic transcription factor TBX1 plays a critical role in cell differentiation during organogenesis of the parathyroid glands. Here we demonstrated that TBX1 mRNA and protein were detected in human adult normal parathyroid tissues (n=3). Immunostaining showed that TBX1 protein was expressed in endothelial CD31+, alfa-SMA+ cells. By contrast, TBX1 mRNA and protein was expressed at higher levels in parathyroid typical adenomas (n=23), where TBX1 staining was...

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Endocrine Abstracts

Stem cell genes are deregulated in parathyroid tumours

The T-box transcription factor TBX1, the candidate gene of 22q11.2 microdeletion/DiGeorge syndrome, is involved in human parathyroid tumorigenesis

BiosciAbstracts